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Serum Concentrations of Some Neuroactive Steroids in Women Suffering from Mixed Anxiety-Depressive Disorder
Authors:Bi?íková  Marie  Tallová  Jaroslava  Hill  Martin  Krausová  Zuzana  Hampl  Richard
Institution:(1) Institute of Endocrinology, Praha, Czech Republic;(2) Department of Clinical Biochemistry, Faculty of Medicine, Masaryk University, Brno, Czech Republic;(3) Institute of Endocrinology, Praha, Czech Republic
Abstract:Concentrations of neurosteroids may be influenced by some physiological or pathological factors. We investigated neuroactive steroids in the serum of women suffering from anxiety-depressive disorder treated with fluoxetine and in a control group, in both the follicular and the luteal phases of the menstrual cycle. Two groups of neuroactive steroids were measured by radioimmunoassays: 1) the positive allosteric modulator of GABAA receptors, allopregnanolone with its precursor progesterone and 2) pregnenolone sulfate and dehydroepiandrosterone sulfate (DHEAS) acting on GABAA receptors by an opposite mechanism. Significantly higher levels of pregnenolone sulfate (p < 0.0001) were found in patients in both phases of the menstrual cycle. Significantly higher values were recorded in pregnenolone (p < 0.001) and 17agr-hydroxy-pregnenolone (p < 0.01) levels in the patients group in the follicular phase. Our results indicate that imbalance in neuroactive steroids may play a negative role in origin and course of psychiatric and neurological disorders.
Keywords:Depression  anxiety  neurosteroids  pregnenolone sulfate  allopregnanolone
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