Two New Coumarins from Fraxinus chinensis Rexb. |
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| Authors: | Dong-Mei Zhang Li-Li Wang Jia Li Li-Hong Hu |
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| Institution: | Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, the Chinese Academy of Sciences, Shanghai 201203, China;National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 201203, China;School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | The ethanol extract of the stem bark of Fraxinus chinensis Roxb. showed good inhibitory bioactivity against VEGF receptor-1 kinase (IC50:13.8 μg/mL). In order to find new and bioactive compounds, the chemical constituents of the stem bark of F. chinensis were investigated and two new coumarins, namely 6'-O-sinapinoyl esculin (compound 1) and 6'-O-vanillyl esculin (compound 2), together with eleven known compounds (compounds 3-13) were isolated.The structures of the two new compounds were identified by their physicochemical properties and spectral analysis, particularly one- and two-dimens ional nuclear magnetic resonance spectral methods. The known compound, oleuropein (compound 11), exhibited moderate activity (IC50:(8.7 ± 1.3) μmol/L) to inhibit VEGF receptor-1 kinase. |
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| Keywords: | coumarins Fraxinus chinensis VEGF receptor-1 kinase |
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