Comparative analysis of JmjC domain-containing proteins reveals the potential histone demethylases in Arabidopsis and rice |
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Authors: | Lu Falong Li Guanglin Cui Xia Liu Chunyan Wang Xiu-Jie Cao Xiaofeng |
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Institution: | ( State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, the Chinese Academy of Sciences;, Beijing 100101, China;Graduate University, the Chinese Academy of Sciences;, Beijing 100039, China ) |
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Abstract: | Histone methylation homeostasis is achieved by controlling the balance between methylation and demethylation to maintain chromatin function and developmental regulation. In animals, a conserved Jumonji C (JmjC) domain was found In a large group of histone demethylases. However, it is still unclear whether plants also contain the JmjC domaincontaining active histone demethylases. Here we performed genome-wide screen and phylogenetic analysis of JmjC domaincontaining proteins in the dicot plant, Arabidopsis, and monocot plant rice, and found 21 and 20 JmjC domain-containing, respectively. We also examined the expression of JmjC domain-containing proteins and compared them to human JmjC counterparts for potential enzymatic activity. The spatial expression patterns of the Arabidopsis JmjC domaincontaining genes revealed that they are all actively transcribed genes. These active plant JmjC domain-containing genes could possibly function in epigenetic regulation to antagonize the activity of the large number of putative SET domaincontaining histone methyltransferase activity to dynamically regulate histone methylation homeostasis. |
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Keywords: | At JMJ demethylase demethylation histone Jumonji C methylation Os JMJ |
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