| RNAi技术研究新进展 |
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| 引用本文： | 周红建,黄松,王雄伟.RNAi技术研究新进展[J].生物技术通报,2010(12). |
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| 作者姓名： | 周红建 黄松 王雄伟 |
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| 作者单位： | 三峡大学第一临床医学院,宜昌,443002 |
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| 摘 要： | RNA干扰(RNAi)是指双链RNA在细胞内特异性地诱导同源互补的mRNA降解,从而阻断相应基因表达的现象。RNAi在生物界中广泛存在,其发生过程主要分为3个阶段:起始阶段、扩增阶段和效应阶段。它在维持基因组稳定、基因表达调控等方面发挥重要生物学作用。随着人们对RNAi研究的不断深入,目前RNA干扰技术作为基因沉默的一个工具,已被广泛用于基因功能研究、疾病的靶点治疗和寻找新的药物靶标等方面的研究。
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| 关 键 词： | RNAi 基因沉默 药物靶标 |
New Development of RNAi Technology |
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| Zhou Hongjian,Huang Song,Wang Xiongwei.New Development of RNAi Technology[J].Biotechnology Bulletin,2010(12). |
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| Authors: | Zhou Hongjian Huang Song Wang Xiongwei |
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| Institution: | Zhou Hongjian Huang Song Wang Xiongwei(First Clinical College of China Three Gorges University,Yichang 443002) |
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| Abstract: | RNA interference refers to the double-stranded RNA in cells specifically induce degradation of homologous mRNA complementary to the phenomenon of blocking the expression of the corresponding gene.RNAi is widespread in the biosphere.The occurrence of RNAi process is divided into three stages:initial stage,the amplification stage,the effect of stage.It plays an important biological role in the maintenance of genome stability,gene expression and regulation.As people study the deepening of the RNAi,the current ... |
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| Keywords: | RNAi Gene silencing Drug target |
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