| RNA干扰非特异性研究进展 |
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| 引用本文： | 韩继波,陈晨,陈始明,陶泽璋.RNA干扰非特异性研究进展[J].生物技术通报,2009(7). |
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| 作者姓名： | 韩继波 陈晨 陈始明 陶泽璋 |
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| 作者单位： | 武汉大学人民医院耳鼻咽喉-头颈外科,武汉,430060 |
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| 基金项目： | 国家自然科学基金面上项目 |
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| 摘 要： | RNA干扰(RNAi)靶向基因治疗是目前研究的热点,其依赖序列特异性的基因表达调节为生物学发展带来重大突破.然而在应用RNAi时所产生的一系列非特异性反应阻碍了RNAi进一步的临床应用,这其中主要包括脱靶基因抑制和内在免疫副反应等.主要从非特异性反应的产生机制、脱靶效应的预测和RNAi非特异性的控制3个方面对近几年研究成果进行综述,探讨临床应用前景.
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| 关 键 词： | RNA干扰 非特异性反应 脱靶效应 免疫副反应 |
Advances of Non-specific Effects on RNAi |
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| Han Jibo,Chen Chen,Chen Shiming,Tao Zezhang.Advances of Non-specific Effects on RNAi[J].Biotechnology Bulletin,2009(7). |
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| Authors: | Han Jibo Chen Chen Chen Shiming Tao Zezhang |
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| Abstract: | At present, RNA interference is being the research focus for gene therapeutic applications. Despite the excitement about this remarkable biological process for sequence specific gene regulation, there are a number of problems that need to be overcome prior to making RNAi as real therapeutic modality, which can include off-target effects and activating innate immune responses. This review discussed mechanistic aspects, precaution and control of off-target effects and gave a prospect for clinical application. |
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| Keywords: | RNAi Non-specific effects Off-target effects Immunostimulation |
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