| 杆状病毒在载体疫苗中应用的研究进展 |
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| 引用本文： | 万婧,周向阳,方维焕.杆状病毒在载体疫苗中应用的研究进展[J].生物技术通报,2012,0(3):35-41. |
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| 作者姓名： | 万婧 周向阳 方维焕 |
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| 作者单位： | 1. 舟山出入境检验检疫局,舟山,316000
2. 浙江大学浙江省动物预防医学重点实验室,杭州,310058 |
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| 基金项目： | 浙江省自然科学基金项目 |
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| 摘 要： | 目前利用来源于哺乳动物的病毒作病毒载体介导动物和人体的免疫应答存在诸多问题,如预存免疫和高致病力重组病毒的出现等。将自然条件下宿主为非哺乳类动物的病毒发展为载体的过程中,由于杆状病毒内在的免疫刺激活性、广泛的组织趋向性及生物安全性使杆状病毒成为疫苗载体发展中的有效工具。随着分子生物学的深入发展,国内外学者应用基因工程技术对杆状病毒转移载体进行了深入研究,并取得丰富的研究成果。对杆状病毒作为转移载体在未来载体疫苗发展中的应用进行综述。
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| 关 键 词： | 杆状病毒 载体疫苗 免疫 传染性疾病 |
Development of Baculovirus as Vaccine Vectors |
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| Wan Jing
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Zhou Xiangyang
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Fang Weihuan.Development of Baculovirus as Vaccine Vectors[J].Biotechnology Bulletin,2012,0(3):35-41. |
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| Authors: | Wan Jing Zhou Xiangyang Fang Weihuan |
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| Institution: | 1Zhoushan Entry-Exit Inspection and Quarantine Bureau,Zhoushan 316000;2Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine,Hangzhou 310058) |
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| Abstract: | Application of viral vectors derived from mammal viruses to mediate immune response in animals and humans has been greatly hindered by the problems associated with pre-existing immunity and associated toxicities.With broad tissue tropism and expanded bio-safety profile suitably supplemented with intrinsic immunostimulatory properties,baculovirus has now evolved as a novel tool for vaccine vector development.Baculovirus as vaccine vectors drew more and more attention.In this paper,the baculovirus as a novel tool in future development were reviewed. |
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| Keywords: | Baculovirus Vaccine vector Immunity Infectious diseases |
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