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金黄色葡萄球菌肠毒素A对H22小鼠移植瘤的抑制作用
引用本文:王雪,孙嘉琳,张云,冯艳敏,陈自辉,李政楠.金黄色葡萄球菌肠毒素A对H22小鼠移植瘤的抑制作用[J].生物技术通报,2009(12).
作者姓名:王雪  孙嘉琳  张云  冯艳敏  陈自辉  李政楠
作者单位:天津科技大学生物工程学院,天津,300457
基金项目:天津市科委资助应用基础研究重点项目 
摘    要:旨在探讨金黄色葡萄球菌肠毒素A(SEA)在KM鼠体内的抑瘤效果.建立H22荷瘤小鼠模型,将20只小鼠随机分为对照组(生理盐水)、低剂量组(15 μg/ml)、中剂量组(25 μg/ml)和高剂量组(50 μg/ml),观察肿瘤生长趋势,计算抑瘤率,通过ELISA检测IL-2的含量.结果显示,给药组肿瘤生长趋势均较对照组缓慢;对照组、低剂量组、中剂量组、高剂量组的抑瘤率分别为0,28.9%,34.0%,51.0%(P<0.05);血清中IL-2含量分别为58.9 pg/ml、83.6 pg/ml、91.8 pg/ml、118.1 pg/ml.金黄色葡萄球菌肠毒素A(SEA)可抑制H22肿瘤的生长,并上调IL-2的分泌.

关 键 词:金黄色葡萄球菌肠毒素A(SEA)  抑瘤作用

The Inhibition Effect of Staphylococcal Enterotoxin A on H22 Solid Tumors in Mice
Wang Xue,Sun Jialin,Zhang Yun,Feng Yanmin,Chen Zihui,Li Zhengnan.The Inhibition Effect of Staphylococcal Enterotoxin A on H22 Solid Tumors in Mice[J].Biotechnology Bulletin,2009(12).
Authors:Wang Xue  Sun Jialin  Zhang Yun  Feng Yanmin  Chen Zihui  Li Zhengnan
Abstract:It was to study inhibition effect of staphylococcal enterotoxin A(SEA)on H22 solid tumors in KM mice.A total of 30 cases of S180 mice were randomly assigned into 4 groups,control(saline),low doses(15 μg/ml),middle doses(25 μg/ml),and high doses(50 μg/ml).The inhibition ratio of tumor growth and value of IL-2 in serum were studied respectively.Results showed that compared to the control group,the tumor growth of the treatment groups was slowly.The tumor-inhibition ratios of control,low doses,middle doses,and high doses were 0,34.0%,28.9% and 51.0%(P<0.05)and the values of IL-2 were 58.9 pg/ml,83.6 pg/ml,91.8 pg/ml,and 118.1pg/ml.Therefore,these results suggest that SEA can inhibit the growth of H22 solid tumors in vivo,and increase the secretion of IL-2.
Keywords:ELISA  IL-2  Staphylococcal enterotoxin A(SEA)  ELISA  IL-2  Antitumor
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