| 刺参甘露糖结合凝集素的生物信息学分析 |
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| 引用本文： | 谢广成,李丹彤,周立敬.刺参甘露糖结合凝集素的生物信息学分析[J].生物技术通报,2011(2). |
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| 作者姓名： | 谢广成 李丹彤 周立敬 |
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| 作者单位： | 1. 大连海洋大学农业部海洋水产增养殖学与生物技术重点开放实验室,大连,116023
2. 中央民族大学生命与环境科学学院,北京,100081 |
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| 基金项目： | 辽宁省教育厅团队项目(2008T021) |
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| 摘 要： | 甘露糖结合凝集素(mannan-binding lectin,MBL)属于C型动物凝集素超家族,特异地结合甘露糖。MBL是宿主起始免疫系统一个重要成分,因此近年来逐渐成为研究的热点。采用生物信息学技术对刺参(Apostichopus japonicus)MBL(AJ-MBL)的两个基因编码的蛋白质结构和功能进行了分析,包括信号肽、分子量、等电点、跨膜结构域、糖基化和磷酸化位点、二级结构和三级结构等,旨在了解其结构特征,为动物免疫反应方面研究提供理论基础。
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| 关 键 词： | 甘露糖结合凝集素 刺参 生物信息学分析 |
Bioinformatics Analysis of Mannan-binding Lectins in Apostichopus japonicus |
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| Xie Guangcheng,Li Dantong,Zhou Lijing.Bioinformatics Analysis of Mannan-binding Lectins in Apostichopus japonicus[J].Biotechnology Bulletin,2011(2). |
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| Authors: | Xie Guangcheng Li Dantong Zhou Lijing |
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| Institution: | Xie Guangcheng1 Li Dantong1 Zhou Lijing2(1Key Laboratory of Mariculture and Biotechnology Certificated by Ministry of Agriculture,Dalian Ocean University,Dalian 116023,2College of Life and Environmental Science,Minzu University of China,Beijing 100081) |
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| Abstract: | Mannan-binding lectins(MBLs)belong to the C-type animal lectin superfamily,which natural high-affinity to mannose.MBLs are important component of innate immunity,responsible for the first line of host defense,so the research in this field became hot in recent years.In this paper,the structure and function of Apostichopus japonicus MBL(AJ-MBL)genes encoding protein such as signal peptide,molecular weight,isoelectric point,transmembrane domain,glycosylation and phosphorylation sites,secondary and tertiary str... |
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| Keywords: | Mannan-binding lectins Apostichopus japonicus Bioinformatics analysis |
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