| 微生物铁蛋白的研究进展 |
| |
| 引用本文： | 高启禹,徐光翠,崔彩霞,张文博.微生物铁蛋白的研究进展[J].生物技术通报,2022(1):269-277. |
| |
| 作者姓名： | 高启禹 徐光翠 崔彩霞 张文博 |
| |
| 作者单位： | 河南新乡医学院生命科学技术学院河南省遗传性疾病与分子靶向药物重点实验室培育基地;兰州大学生命科学学院;河南新乡医学院公共卫生学院 |
| |
| 基金项目： | 国家自然科学基金项目(81370916);新乡医学院博士启动项目(XYBSKYZZ202125)。 |
| |
| 摘 要： | 铁蛋白作为一种重要的铁储存蛋白,在不同的微生物体中普遍存在.通过对典型的微生物铁蛋白分子(FTN)的结构及其功能的归纳分析发现,铁蛋白依赖其独特的结构特点,在铁的补充、转运、氧化、成核和储存中扮演着重要作用,也对生物体内的多种生物化学反应影响显著.同时借助基因工程技术对铁蛋白进行相应的分子改造,增加了其作为纳米载体的应...
|
| 关 键 词： | 铁蛋白 铁氧化酶 生物矿化 笼状结构 纳米载体 |
Research Progress in Microbial Ferritin |
| |
| GAO Qi-yu,XU Guang-cui,CUI Cai-xia,ZHANG Wen-bo.Research Progress in Microbial Ferritin[J].Biotechnology Bulletin,2022(1):269-277. |
| |
| Authors: | GAO Qi-yu XU Guang-cui CUI Cai-xia ZHANG Wen-bo |
| |
| Institution: | (College of Life Science and Technology,Xinxiang Medical University,Henan Key Laboratory of Hereditary Disease and Molecular Target Drug Therapy(Cultivating Base),Xinxiang 453003;School of Life Sciences,Lanzhou University,Lanzhou 730000;College of Public Health,Xinxiang Medical University,Xinxiang 453003) |
| |
| Abstract: | Ferritin(FTN),an important iron storage protein,is ubiquitous in different microorganisms.Based on the summarized analysis of the structure and function of typical ferritin,it is found that the unique structural characteristics of ferritin plays an important role in the supplement,transport,oxidation,nucleation and storage of iron,and also has a significant impact on various biochemical reactions in organisms.Moreover,the molecular modification of ferritin by genetic engineering technology will expand its application as nanocarrier.The special self-assembly characteristics of ferritin make it a potential carrier for drugs or other substances.Therefore,in order to further explore the characteristics and mechanism of ferritin in microorganisms,the structural characteristics of microbial ferritin,the role and release mechanism of iron,the regulation and storage of iron,the molecular modification of ferritin and its perspectives are systematically summarized in this review. |
| |
| Keywords: | ferritin ferroxidase biomineralization cage structure protein nanoparticles |
| 本文献已被 维普 等数据库收录！ |
|
