| DNA疫苗的分子佐剂应用研究进展 |
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| 引用本文： | 赵渝,赵冰,陆苹.DNA疫苗的分子佐剂应用研究进展[J].生物技术通报,2002(5):10-12,16. |
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| 作者姓名： | 赵渝 赵冰 陆苹 |
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| 作者单位： | 1. 上海师范大学生命与环境科学学院,上海,200234
2. 上海交通大学生物技术研究所,上海,201011 |
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| 摘 要： | DNA疫苗因在动物尤其是大型动物与人类中诱发较低的免疫反应而严重影响其推广应用。介绍提高与调节DNA疫苗诱导反应的策略：（1）以细胞因子表达质控为佐剂；（2）以质粒编码的趋化因子与共刺激分子为佐剂；（3）以CPG ODN为佐剂。
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| 关 键 词： | DNA疫苗 分子佐剂 研究进展 应用 质粒 趋化因子 CPG ODN |
Recent Advances in Application of Genetic Immunoadjuvant for DNA Vaccines |
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| Zhao Yu,Zhao Bing,Lu Ping.Recent Advances in Application of Genetic Immunoadjuvant for DNA Vaccines[J].Biotechnology Bulletin,2002(5):10-12,16. |
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| Authors: | Zhao Yu Zhao Bing Lu Ping |
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| Institution: | Zhao Yu1 Zhao Bing2 Lu Ping2 |
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| Abstract: | Because of the Low immunoreaction the DNA vaccine induced in big animal and human being,the application of DNA vaccine was severely limited. Despite considerable effort expended on improving DNA vaccine delivery, there are several complementary strategies have been used to improve and modulate the immune response induced by DNA vaccines(1) supplementing plasmid encoding cytokine (2) use plasmid encoding costimulatory molecules and chemokine as adjuvant (3) CPG ODN as adjuvant. |
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| Keywords: | DNA vaccine Genetic adjuvant Plasmid Chemokine CPG ODN |
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