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| 混合菌发酵L-山梨糖生产Vc前体2-酮基-L-古龙酸研究进展 | |
| 引用本文： | 吕淑霞,赵朔,杨宇,张忠泽,陈宏权.混合菌发酵L-山梨糖生产Vc前体2-酮基-L-古龙酸研究进展[J].生物技术通报,2011,0(5). |
| 作者姓名： | 吕淑霞 赵朔 杨宇 张忠泽 陈宏权 |
| 作者单位： | 1. 沈阳农业大学生物科学技术学院,沈阳,110866 2. 中国科学院沈阳应用生态研究所,沈阳,110016 3. 东北制药总厂Vc公司,沈阳,110028 |
| 基金项目： | 沈阳市科学技术计划项目 |
| 摘 要： | 利用混合菌发酵L-山梨糖生产2-酮基-L-古龙酸(2-KCA),再经化学转化合成维生素C(Vc),是我国工业生产Vc的主要途径,具有简化工艺,减少污染,降低能耗等诸多优点.从菌系组合、菌种选育、代谢途径与酶学特性、工程菌构建、伴生作用机制及发酵工艺等方面出发,综述混合菌发酵L-山梨糖生产Vc前体2-KGA的研究现状和最新进展,并提出进一步研究和探索的方向. |
| 关 键 词： | 混合菌发酵 L-山梨糖 2-酮基-L-古龙酸 |
Research Progress on Vc Precursor of 2-KGA Production Through Mixed Fermentation from L-sorbose |
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| Lv Shuxia,Zhao Shuo,Yang Yu,Zhang Zhongze,Chen Hongquan.Research Progress on Vc Precursor of 2-KGA Production Through Mixed Fermentation from L-sorbose[J].Biotechnology Bulletin,2011,0(5). | |
| Authors: | Lv Shuxia Zhao Shuo Yang Yu Zhang Zhongze Chen Hongquan |
| Institution: | Lv Shuxia1 Zhao Shuo1 Yang Yu1 Zhang Zhongze2 Chen Hongquan3(1College of Biological Science and Technology,Shenyang Agricultural University,Shenyang 110866,2Institute of Applied Ecology,Academia Sinica,Shenyang 110016,3Northeast Pharmaceutical General Factory of Vitamin C Company,Shenyang 110028) |
| Abstract: | The mixed fermentation to produce 2-keto-L-gulonic acid(2-KGA),as the precursor of Vitamin C(Vc) transform from L-sorbose,is the major method of Vc industrial production in China.This method has the advantages of simple operation,less pollution and lower consumption.In this paper,the latest progresses of mixed fermentation to produce 2-KGA are reviewed from the aspects of strains combination,high-yielding strains screening,metabolic mechanism,enzymatic characteristics,construction of the recombinant strains... |
| Keywords: | Mixed fermentation L-sorbose 2-keto-L-gluonic acid |
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