| RNAi技术及其应用 |
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| 引用本文： | 伍林涛,阮颖,彭琦,张源,刘春林.RNAi技术及其应用[J].生物技术通报,2007(4):82-84,96. |
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| 作者姓名： | 伍林涛 阮颖 彭琦 张源 刘春林 |
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| 作者单位： | 1. 湖南农业大学农学院,长沙,410128
2. 作物基因工程湖南省重点实验室,长沙,410128 |
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| 基金项目： | 湖南农业大学校人才基金 |
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| 摘 要： | RNA干扰是指外源双链RNA进入细胞以后引起的与其同源mRNA特异性降解的现象,它参与真核生物抵抗病毒侵染,阻断转座子的异常活动,调控基因表达。RNAi已成为一种进行基因功能分析的强有力的工具,并有望成为最有潜力的基因干预治疗方法。
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| 关 键 词： | RNA干扰 基因沉默 基因治疗 |
| 修稿时间： | 2007-02-06 |
RNA interference Technique and the Using |
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| Wu Lintao,Ruan Ying,Peng Qi,Zhang Yuan,Liu Chunlin.RNA interference Technique and the Using[J].Biotechnology Bulletin,2007(4):82-84,96. |
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| Authors: | Wu Lintao Ruan Ying Peng Qi Zhang Yuan Liu Chunlin |
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| Institution: | 1College of Agronomy Hunan Agricultural University , Changsha 410128 ; 2 Crop Gene Engineering Key Laboratory of Hunan Province, Changsha 410128 |
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| Abstract: | RNA interference(RNAi)is an evolutionarily conserved eukaryotic adaptive response that lead to the specific degradation of target mRNA species in response to cellular exposure to homologous double-stranded RNA molecules.It is to both endogenous pathogenic nucleic acids,and regulates the expression of protein-coding genes.RNAi is now a powerful instrument for functional genomic analyses and will be a potentionally useful method in highly specific ds RNA based gene-silencing therapeutics. |
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| Keywords: | mRNA |
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