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血小板在凝血中作用的动力学模型及仿真
引用本文:许传青,曾衍钧.血小板在凝血中作用的动力学模型及仿真[J].生物物理学报,2000,16(4):806-812.
作者姓名:许传青  曾衍钧
作者单位:北京工业大学生物力学和医学信息研究所,北京100022
基金项目:北京自然科学基金资助项目!(3982005)
摘    要:在生化实验的基础上提出了血小板在凝血中作用的动力学模型,通过定性分析和数值模拟,得到:系统的启动存在一阈值,该阈值与血小板和凝血因子作用的吸附解离常数有密切的关系,即与血小板的存在与否直接相关;血小板的激活比率对系统的正平衡点的稳定性有重要的影响,与凝血启动后的最终状态有关;当刺激强度较小时,因子Ⅷ和Ⅸ对系统的解在定性与定量上没有明显的影响;当刺激强度较大时,因子Ⅷ和Ⅸ在凝血瀑布机制中起级联放大作

关 键 词:血小板  凝血  动力学模型  稳定性分析

DYNAMIC MODEL ON ROLES OF PLATELET IN THE BLOODCOAGULATION AND THE SIMULATION
XU Chuan-qing,ZENG Yan-jun.DYNAMIC MODEL ON ROLES OF PLATELET IN THE BLOODCOAGULATION AND THE SIMULATION[J].Acta Biophysica Sinica,2000,16(4):806-812.
Authors:XU Chuan-qing  ZENG Yan-jun
Abstract:On the basis of biochemical experiments,a mathematical model about the action of platelets in blood coagulation is provided. Through qualitative analysis and mathematical simulation, a series of conclusions are drawn about the influence of the activating rate of factor VIII and factor IX on the generation of thrombin. It is evident that the pro-coagulation stimulus must exceed a threshold value to initiate the coagulation cascade. The value is related to the rate of activating of platelets, the binding constant d22. The stability of the fixed value is also related to the pro-coagulation stimulus. The influence of the stimulus strength and activated rate parameter of platelet on thrombin is evaluated. The proportion of platelets activated at any given time is termed c. To each c, a maximum concentration of thrombin is obtained. It shows when the level of factor IX is below 1% of normal level, the rate of thrombin generation reduces dramatically resulting in severe bleeding tendency.
Keywords:Blood coagulation  Platelet  Coagulation  Dynamic model  Stability analysis
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