| 线粒体蛋白质的转运 |
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| 引用本文： | 马军,孙飞.线粒体蛋白质的转运[J].生物物理学报,2010(10). |
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| 作者姓名： | 马军 孙飞 |
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| 作者单位： | 中国科学院生物物理研究所;生物大分子国家重点实验室; |
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| 基金项目： | 国家重点基础研究发展规划资助项目(“973”计划)(2006CB806506,2006CB911001); 国家自然科学基金(30721003,30970569) |
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| 摘 要： | 线粒体含有约1000种蛋白质,其中99%由细胞核DNA编码,在细胞质核糖体上合成后被分别转运至线粒体的内膜或外膜上、基质或膜间隙中。由众多分子机器组成的线粒体蛋白质转运系统参与了该生物学过程的执行。线粒体DNA编码的13种蛋白质也由该系统转运至线粒体内膜。本文就线粒体蛋白质转运系统中线粒体前体蛋白质的定位分选信号、转运复合物和转运途径作简要介绍。
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| 关 键 词： | 蛋白质转运 前导序列 TOM复合物 TIM23复合物 TIM22复合物 |
Translocation of Mitochondrial Proteins |
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| MA Jun,SUN Fei National Laboratory of Biomacromolecular.Translocation of Mitochondrial Proteins[J].Acta Biophysica Sinica,2010(10). |
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| Authors: | MA Jun SUN Fei National Laboratory of Biomacromolecular |
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| Institution: | MA Jun,SUN Fei National Laboratory of Biomacromolecular,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China |
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| Abstract: | There are about 1000 proteins located in mitochondria, of which 99% are encoded by nucleic DNA, synthesized by cytosolic ribosomes and then imported into one of the four mitochondrial compartments:matrix, inner membrane, intermembrane space and outer membrane.Several intricate molecular machines are dedicated to catalyze these processes as the mitochondrial protein translocation system.Thirteen proteins encoded by mitochondrial DNA are also translocated into inner membrane by this system.The various targeti... |
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| Keywords: | Protein translocation Presequence TOM complex TIM23 complex TIM22 complex |
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