| 光学分子影像技术及其在药物研发领域的应用 |
| |
| 引用本文： | 刘静,张国君.光学分子影像技术及其在药物研发领域的应用[J].生物物理学报,2011(8). |
| |
| 作者姓名： | 刘静 张国君 |
| |
| 作者单位： | 汕头大学医学院肿瘤研究中心;汕头大学医学院附属肿瘤医院乳腺中心; |
| |
| 基金项目： | 国家自然科学基金项目(30973377); 广东省自然科学基金项目(9151800102000000); 广东省高等学校人才引进项目(粤教师[2008]86号)~~ |
| |
| 摘 要： | 光学分子影像技术是一种发展迅速的生物医学影像技术,能够利用生物发光技术或荧光蛋白等,对生物体内特定的生物过程进行无创的定性或定量研究。应用该技术可以对药物进行筛选,选取具有潜在治疗效果的药物进行后续研究,而终止对可能无效药物的研究,同时可以评价药物对肿瘤的代谢、增殖、血管形成、凋亡和组织乏氧等方面的影响。本文主要介绍光学分子影像技术及其在药物研发,尤其是抗肿瘤药物研发领域的应用。
|
| 关 键 词： | 光学成像 药物研发 肿瘤学 动物模型 |
Optical Molecular Imaging and Its Application in Drug Discovery and Development |
| |
| LIU Jing,ZHANG Guojun, .Cancer Research Center,Shantou University Medical College,Shantou,Guangdong ,China,.Breast Center,Cancer Hospital of Shantou University Medical College,Guangdong.Optical Molecular Imaging and Its Application in Drug Discovery and Development[J].Acta Biophysica Sinica,2011(8). |
| |
| Authors: | LIU Jing ZHANG Guojun Cancer Research Center Shantou University Medical College Shantou Guangdong China Breast Center Cancer Hospital of Shantou University Medical College Guangdong |
| |
| Institution: | LIU Jing1,ZHANG Guojun1,2 1.Cancer Research Center,Shantou University Medical College,Shantou,Guangdong 515041,China,2.Breast Center,Cancer Hospital of Shantou University Medical College,Guangdong 515031 |
| |
| Abstract: | Optical molecular imaging is a rapidly developed biomedical technology that enables the non-invasive assessment of biological and biochemical processes in vivo by bioluminescence or fluorescent proteins.Such technologies therefore have the potential to screen candidates that seem most likely to be successful or to halt the development of drugs that seem likely to ultimately fail,and to evaluate drug effects on tumor metabolism,proliferation,angiogenesis,apoptosis,and tissue hypoxia.Here,with an emphasis on ... |
| |
| Keywords: | Optical imaging Drug discovery Oncology Animal model |
| 本文献已被 CNKI 等数据库收录！ |
|
