| 分子影像监测血管内皮细胞生长因子预处理促进体外和体内脂肪间充质干细胞存活与增殖的研究 |
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| 引用本文： | 范伟伟,王亚斌,张荣庆,李聪叶,李霜,曹丰.分子影像监测血管内皮细胞生长因子预处理促进体外和体内脂肪间充质干细胞存活与增殖的研究[J].生物物理学报,2011(4):345-354. |
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| 作者姓名： | 范伟伟 王亚斌 张荣庆 李聪叶 李霜 曹丰 |
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| 作者单位： | 第四军医大学西京医院心血管内科;第四军医大学西京医院分子影像研究中心; |
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| 基金项目： | 国家自然科学基金项目(81090274,30970845); 西京医院助推计划重大项目(XJZT08Z04)~~ |
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| 摘 要： | 干细胞疗法为缺血性心血管病的组织再生带来希望,然而体内移植后干细胞的不良转归严重制约了其治疗效果.研究表明,血管内皮细胞生长因子(vascular endotllelial growth factor,VEGF)或可对干细胞产生保护作用;同时,分子影像可作为干细胞研究的有力手段,实现体内外干细胞生物学过程的可视化与实时...
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| 关 键 词： | 分子影像 间充质干细胞 血管内皮细胞生长因子 |
Molecular Imaging for Monitoring Survival and Proliferation of Adipose Derived Mesenchymal Stem Cells in vitro and in vivo after Pretreatment with VEGF |
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| FAN Weiwei,WANG Yabin,ZHANG Rongqing,LI Congye,LI Shuang,CAO Feng.Molecular Imaging for Monitoring Survival and Proliferation of Adipose Derived Mesenchymal Stem Cells in vitro and in vivo after Pretreatment with VEGF[J].Acta Biophysica Sinica,2011(4):345-354. |
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| Authors: | FAN Weiwei WANG Yabin ZHANG Rongqing LI Congye LI Shuang CAO Feng |
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| Institution: | FAN Weiwei,WANG Yabin,ZHANG Rongqing,LI Congye,LI Shuang,CAO Feng Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Molecular Imaging Center,Xi'an 710032,China |
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| Abstract: | Although stem cell therapy holds promise for the regenerative treatment of ischemic heart disease,the tragic fate of engrafted stem cells is still a hurdle for the therapeutic effect.Previous studies showed that molecular imaging could be a realtime and quantitative effective approach to visualize and monitor stem cells,while vasoactive factors such as vascular endothelial growth factor(VEGF) may have protective effect on the stem cell.In this study,adipose tissue derived mesenchymal stem cells(ADMSCs),whic... |
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| Keywords: | Molecular imaging Mesenchymal stem cells VEGF |
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