| 双靶点分子探针68Ga-RGD-BBN用于乳腺癌的microPET显像 |
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| 引用本文： | 赵慧云,刘妍,贾兵,王凡,刘昭飞.双靶点分子探针68Ga-RGD-BBN用于乳腺癌的microPET显像[J].生物物理学报,2011(4):267,335-344. |
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| 作者姓名： | 赵慧云 刘妍 贾兵 王凡 刘昭飞 |
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| 作者单位： | 北京大学医学同位素研究中心;北京大学基础医学院放射医学教研室; |
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| 基金项目： | 国家自然科学基金项目(81028009,81000625,30930030,30900373和30870728)~~ |
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| 摘 要： | 精氨酸-甘氨酸-天冬氨酸(Arg-Gly-Asp,RGD)和蛙皮素(bombesin,BBN)多肽分别能够特异性识别整合素αvβ3和胃泌素释放肽受体(gastrin releasing peptide receptor,GRPR).我们用谷氨酸将RGD和BBN连接制备成RGD-BBN异源二聚体多肽,用双功能连接剂NOT...
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| 关 键 词： | RGD-BBN 整合素αvβ3 GRPR 乳腺癌 microPET显像 |
MicroPET Imaging of Breast Cancer with a Dual-Targeted Molecular Probe ~(68)Ga-RGD-BBN |
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| ZHAO Huiyun,LIU Yan,JIA Bing,WANG Fan,LIU Zhaofei, .Medical Isotopes Research Center,Peking University,Beijing ,China.MicroPET Imaging of Breast Cancer with a Dual-Targeted Molecular Probe ~(68)Ga-RGD-BBN[J].Acta Biophysica Sinica,2011(4):267,335-344. |
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| Authors: | ZHAO Huiyun LIU Yan JIA Bing WANG Fan LIU Zhaofei Medical Isotopes Research Center Peking University Beijing China |
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| Institution: | ZHAO Huiyun1,LIU Yan1,2,JIA Bing1,WANG Fan1,LIU Zhaofei1,2 1.Medical Isotopes Research Center,Peking University,Beijing 100191,China,2.Department of Radiation Medicine,School of Basic Medical Sciences |
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