| 咖啡酸苯乙酯衍生物抑制红细胞溶血和HL-60细胞增殖活性的构效关系研究 |
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| 引用本文： | 钱益平,王琪,曹小燕,周波.咖啡酸苯乙酯衍生物抑制红细胞溶血和HL-60细胞增殖活性的构效关系研究[J].生物物理学报,2010(4). |
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| 作者姓名： | 钱益平 王琪 曹小燕 周波 |
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| 作者单位： | 兰州大学功能有机分子化学国家重点实验室; |
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| 基金项目： | 国家自然科学基金面上项目(20972063)~~ |
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| 摘 要： | 蜂胶中的主要成分咖啡酸苯乙酯作为重要的抗氧化剂和癌预防试剂分子,引起了人们相当的兴趣。为了研究其构效关系,作者通过酰基化反应合成了6个咖啡酸苯乙酯衍生物,即:咖啡酸苯乙酯(caffeic acid phenethyl ester,CAPE)、芥子酸苯乙酯(sinapic acid phenethyl ester,SAPE)、阿魏酸苯乙酯(ferulic acid phenethyl ester,FAPE)、4-羟基肉桂酸苯乙酯(4-hydroxycinnamicacid phenethyl ester,4-HCAPE)、3,5-二羟基肉桂酸苯乙酯(3,5-dihydroxycinnamic acidphenethyl ester,3,5-DHCAPE)和3-羟基肉桂酸苯乙酯(3-hydroxycinnamic acid phenethyl este,3-HCAPE)。以水溶性偶氮引发剂2,2'-偶氮二(2-脒基丙烷)二盐酸盐诱导的红细胞溶血为模型,研究了它们的抗氧化活性。根据实验测得的有效抑制溶血时间,其活性顺序为:CAPE≈4-HCAPE>SAPE>FAPE>3,5-DHCAPE>3-HCAPE。其活性显著...
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| 关 键 词： | 咖啡酸苯乙酯 抗氧化剂 构效关系 红细胞 癌预防试剂 |
Structure-Activity Relationship for Anti-Haemolysis and Cytotoxicity Against HL-60 Cells of Caffeic Acid Phenethyl Ester Derivatives |
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| QIAN Yiping,WANG Qi,CAO Xiaoyan,ZHOU Bo State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou ,China.Structure-Activity Relationship for Anti-Haemolysis and Cytotoxicity Against HL-60 Cells of Caffeic Acid Phenethyl Ester Derivatives[J].Acta Biophysica Sinica,2010(4). |
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| Authors: | QIAN Yiping WANG Qi CAO Xiaoyan ZHOU Bo State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou China |
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| Institution: | QIAN Yiping,WANG Qi,CAO Xiaoyan,ZHOU Bo State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000,China |
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| Abstract: | Caffeic acid phenethyl ester has been identified as an active component of propolis, and its antioxidant and cancer chemoprevention activities have attracted considerable attention. In order to reveal the structure-activity relationship of caffeic acid phenethyl ester derivatives (ArOHs), the authors synthesized six ArOHs, caffeic acid phenethyl ester (CAPE), ferulic acid phenethyl ester (FAPE), 4-hydroxycinnamic acid phenethyl ester (4-HCAPE), sinapic acid phenethyl ester (SAPE), 3,5-dihydroxycinnamic acid... |
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| Keywords: | Caffeic acid phenethyl ester Antioxidant Structure-activity relationship Red blood cell Cancer chemoprevention |
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