| 血红素氧合酶-1对肝癌作用的研究进展 |
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| 引用本文： | 杨世英,宋阳,王翔,钟莉.血红素氧合酶-1对肝癌作用的研究进展[J].生物物理学报,2012(5):396-401. |
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| 作者姓名： | 杨世英 宋阳 王翔 钟莉 |
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| 作者单位： | 重庆大学生物工程学院,"111计划"生物力学与组织修复工程基地(重庆大学),教育部生物流变学与技术重点实验室 |
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| 基金项目： | 留学回国人员科研启动基金(2011-508);“863”计划项目(2011AA02A103)~~ |
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| 摘 要： | 血红素氧合酶-1(heme oxygenase,HO-1)是细胞内的一种可诱导的保护性酶,具有抗氧化、抗炎、抗凋亡等作用。它在肿瘤细胞(如肝癌细胞)中的表达一般会增强,能影响肿瘤细胞的增殖等生物学行为。一方面,HO-1能促进肝癌细胞的生长和扩散,并通过减少氧化应激产生的氧自由基而对肝癌细胞发挥保护作用,使肝癌细胞对治疗产生抵抗性。另一方面,HO-1使肝移植治疗晚期肝癌中的免疫排斥降低,提高肝移植的成功率。本文简要概括了HO-1对肝癌发生进展的影响,并阐述了HO-1在肝移植方面的重要作用,这可能对抗肝癌药物的研发及肝癌的治疗具有一定的指导意义。
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| 关 键 词： | 血红素氧合酶-1 肝癌 氧自由基 免疫抑制 |
Research Progress in Effects of Heme Oxygenase-1 on Hepatoma |
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| YANG Shiying,SONG Yang,WANG Xiang,ZHONG Li.Research Progress in Effects of Heme Oxygenase-1 on Hepatoma[J].Acta Biophysica Sinica,2012(5):396-401. |
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| Authors: | YANG Shiying SONG Yang WANG Xiang ZHONG Li |
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| Institution: | The Base of "111 Project" for Biomechanics & Tissue Repair Engineering,Key Laboratory of Biorheological Science and Technology,Ministry of Education,Bioengineering College,Chongqing University,Chongqing 400044,Chin |
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| Abstract: | Heme oxygenase-1(HO-1) is an inducible and protective enzyme,and has anti-oxidation,anti-inflammation and anti-apoptosis function.The expression of HO-1 generally elevated in tumors(such as hepatocellular carcinoma,HCC) and could effect on the proliferation and other biological behaviors of tumor cells.HO-1 can provide protection to cells through decreasing the levels of reactive oxygen species and promoting the growth and metastasis of HCC.On the other side,HO-1 can cause immuno-suppression,therefore,it could improve the success rate of liver transplantation.Based on recent achievement in studies of HCC,this review summarized the influence of HO-1 on HCC and liver transplantation,and may provide instructive significance for further studies on the development of anti-HCC drugs and their applications to liver cancer treatment. |
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| Keywords: | Heme oxygenase-1 Hepatocellular carcinoma Reactive oxygen species Immuno-suppression |
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