| 用于蛋白质同源模建及三维结构预测的结构比较方法 |
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| 引用本文： | 汤海旭,丁达夫.用于蛋白质同源模建及三维结构预测的结构比较方法[J].生物物理学报,1995,11(1):60-66. |
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| 作者姓名： | 汤海旭 丁达夫 |
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| 作者单位： | 中国科学院上海生物化学研究所 |
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| 基金项目： | 国家863—103—22—1课题,国家自然科学基金,上海生命科学联合开放实验室的资助 |
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| 摘 要： | 继前面的工作把测试蛋白从三族扩大到十一族，寻求联配参数的普适“缺省值“；比较不同的主链曲率和挠率的计算方法，进一步确认主链的折红红分几何刻划方法的有效性；寻找有效的可变缺失突变惩罚函数的形式。结果表明，编制的蛋白质多重联配软件系统是满意的，可用于蛋白质三维结构预测。
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| 关 键 词： | 结构联配 同源模建 三维结构 预测 蛋白 |
A METHOD OF STRUCTURE COMPARISON FOR PROTEIN KNOWLEDGE BASED MODELLING AND TERTIARY STRUCTURE PREDICTION |
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| Tang Haixu, Ding Dafu.A METHOD OF STRUCTURE COMPARISON FOR PROTEIN KNOWLEDGE BASED MODELLING AND TERTIARY STRUCTURE PREDICTION[J].Acta Biophysica Sinica,1995,11(1):60-66. |
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| Authors: | Tang Haixu Ding Dafu |
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| Abstract: | The abc are to get the generic "default parameters" for use in the comparison program CONTRAST which aligns protein sequenes based on their 3D-structure, to confirm the efficiency of the differential -geometric representation of protein backbone by comparing 3 different algorithms of the curvatures and tortions, and tO find apropriate gap penalty function.The results from 11 families alignments including 64 proteins show that the CONTRAST program are satisfied and could be used in the protein 3D structure prediction. |
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| Keywords: | Multiple structure alignment Knowledge based modelling Tertiary structure prediCtion |
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