| 棕榈酸的组织吸收分布及对骨骼肌胰岛素抵抗的影响 |
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| 引用本文： | 彭恭,刘延波,李凌海,刘平生.棕榈酸的组织吸收分布及对骨骼肌胰岛素抵抗的影响[J].生物物理学报,2012(1):45-52. |
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| 作者姓名： | 彭恭 刘延波 李凌海 刘平生 |
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| 作者单位： | 吉林大学第一医院,转化医学研究院;贵州大学生命科学学院;中国科学院生物物理研究所 |
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| 基金项目： | 国家自然科学基金项目(30871129,30971431)~~ |
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| 摘 要： | 脂肪酸代谢紊乱是Ⅱ型糖尿病的主要致病因素之一。棕榈酸是血液中含量最高的游离脂肪酸。我们建立了大鼠颈静脉置管输注棕榈酸的模型,发现血液中的大部分棕榈酸被骨骼肌组织所吸收。以棕榈酸处理的C2C12骨骼肌细胞为实验模型发现,棕榈酸进入骨骼肌细胞后的中间代谢产物(磷脂和甘油二酯)的累积,会造成内质网应激及胰岛素抵抗。提示血液中棕榈酸含量的升高可能通过骨骼肌的胰岛素抵抗机制,影响Ⅱ型糖尿病的发生和发展。
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| 关 键 词： | 棕榈酸 胰岛素抵抗 骨骼肌 脂肪酸静脉输注 |
Insulin Resistance Is Correlated with Palmitic Acid Uptake in Skeletal Muscle Cells |
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| PENG Gong,LIU Yanbo,LI Linghai,LIU Pingsheng.Insulin Resistance Is Correlated with Palmitic Acid Uptake in Skeletal Muscle Cells[J].Acta Biophysica Sinica,2012(1):45-52. |
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| Authors: | PENG Gong LIU Yanbo LI Linghai LIU Pingsheng |
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| Institution: | 1.Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2.College of Life Science,Guizhou University,Guiyang 550025,China 3.Institute of Translational Medicine,the First Hospital of Jilin University,Changchun 130021,China |
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| Abstract: | The aberration of palmitic acid metabolism is one of the key factors that have linked to the development and progression of type II diabetes.Palmitic acid is the most abundant free fatty acid in human blood.The mechanism how palmitic acid affects animal body energy homeostasis and leads to such metabolic disease remains elusive.Therefore,we established a rat model with venous fatty acid infusion to investigate the function of palmitic acid in animal blood.Using this model system,we found that half-life of palmitic acid in rat blood was about 30 min and more than half of palmitic acid was uptaken by skeletal muscle.Our further experiments using skeletal muscle cell line C2C12 revealed that palmitic acid was mainly converted to phospholipids,diacylglyceride and triglyceride.Similar to previous studies including our own,accumulated palmitic acid metabolites induced insulin resistance.Taken together,increasing concentration of blood palmitic acid may cause type II diabetes through insulin resistance in skeletal muscle. |
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| Keywords: | Palmitic acid Insulin resistance Skeletal muscle Venous fatty acid infusion |
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