| 羟自由基对人红细胞磷脂酰乙醇胺脂质体相变性质的影响 |
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| 引用本文： | 宋剑陶,陈建文,鲁崎峿,黄芬.羟自由基对人红细胞磷脂酰乙醇胺脂质体相变性质的影响[J].生物物理学报,1993,9(2):215-219. |
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| 作者姓名： | 宋剑陶 陈建文 鲁崎峿 黄芬 |
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| 作者单位： | 中国科学院生物物理研究所,北京100101 |
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| 摘 要： | 研究了过氧化氢与亚铁离子体系产生的羟自由基对人红细胞膜磷脂酸乙醇胺(PE)脂质体相变性质的影响.结果表明,羟自由基导致脂质体不饱和脂肪酸链的含量明显降低和丙二醛(MDA)含量显著升高,同时其膜流动性随之下降.在室温下,羟自由基诱使PF脂质体冰冻断裂面出现脂质颗粒,说明羟自由基通过脂质过氧化作用可促进PE脂质体从脂双层转变为非双层结构.
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| 关 键 词： | 羟 自由基 非双层结构 红细胞 |
INFLUENCE OF HYDROXYL FREE RADICAL ON THE PHASE BEHAVIOR OF HUMAN ERYTHROCYTE-PE LIPOSOMES |
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| Abstract: | The influence of hydroxyl free radical generated from H2O2-Fe2+ system on the phase behavior of human erythrocyte - PE liposomes has been investigated. The results show that the treatment of H2O2-Fe2+ resulted in the decrease of unsaturated acyl chain compositions and the formation of malondiadehyde (MDA), meanwhile the membrane fluidity of the liposomes decreased markedly. Under room temperature, the appearence of lipidic particles on the freeze - fracture face of the liposomes was observed, indicating that hydroxyl free radical could promote the formation of non -bilayer structure in human erythrocyte - PE liposomes through lipid peroxidation. |
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| Keywords: | Hydroxyl Free Radical Human Erythrocyte-PE Non-bilayer Structure |
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