Solid Dispersions of Imidazolidinedione by PEG and PVP Polymers with Potential Antischistosomal Activities |
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Authors: | Francimary L Guedes Boaz G de Oliveira Marcelo Z Hernandes Carlos A De Simone Francisco J B Veiga Maria do Carmo A de Lima Ivan R Pitta Suely L Galdino Pedro José Rolim Neto |
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Institution: | 1.Laboratório de Tecnologia dos Medicamentos,UFPE,Recife,Brazil;2.Laboratório de Química Teórica Medicinal,UFPE,Recife,Brazil;3.Laboratório de Cristalografia e Modelagem Molecular-LaboCriMM,UFAL,Maceio,Brazil;4.Laboratório de Tecnologia Farmacêutica de Faculdade de Farmácia,Universidade de Coimbra,Coimbra,Portugal;5.Laboratório de Planejamento e Síntese de Fármacos-LPSF,UFPE,Recife,Brazil |
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Abstract: | Solid dispersions have been used as a strategy to improve the solubility, dissolution rate, and bioavailability of poor water-soluble
drugs. The increase of the dissolution rate presented by (5Z)-3-(4-chloro-benzyl)-5-(4-nitro-benzylidene)-imidazolidine-2,4-dione (LPSF/FZ4) from the solid dispersions is related to
the existence of intermolecular interactions of hydrogen bond type (>N–H...O<) between the amide group (>N–H) of the LPSF/FZ4 and the ether group (–O–) of the polyethyleneglycol polymer, or the carbonyl
(C=O) of the polyvinylpyrrolidone polymer (PVP). The intensity of these interactions is directly reflected in the morphology
acquired by LPSF/FZ4 in these systems, where a new solid phase, in the form of amorphous aggregates of irregular size, was
identified through scanning electron microscopy and confirmed in the characterizations achieved using X-ray diffraction and
thermal analysis of DSC. The solid dispersions with the polymer PVP, in higher concentrations, were revealed to be the best
option to be used in the formulations of LPSF/FZ4 in both theoretical and experimental studies. |
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