Poly(D,L-Lactide-Co-Glycolide) microspheres containing 5-fluorouracil: Optimization of process parameters |
| |
| Authors: | Rajesh H Parikh Jolly R Parikh Rajesh R Dubey Heena N Soni Kishor N Kapadia |
| |
| Institution: | (1) Department of Pharmaceutics and Pharmaceutical Technology, AR College of Pharmacy and GH Patel Institute of Pharmacy, Gujarat, India;(2) Institute of Science and Technology for Advanced Studies and Research, 388120 Vallabh Vidyanagar, Gujarat, India |
| |
| Abstract: | The objective of this research was to optimize the processing parameters for poly(D,L-lactide-coglycolide) (PLGA) microspheres
of 5-fluorouracil (5-FU) and to mathematically relate the process parameters and properties of microspheres. Microspheres
were prepared by a water-in-oil-in-water emulsion solvent evaporation technique. A 32 factorial design was employed to study the effect of the volume of the internal phase of the primary emulsion and the volume
of the external phase of the secondary emulsion on yield, particle size, and encapsulation efficiency of microspheres. An
increase in the volume of the internal phase of the primary emulsion resulted in a decrease in yield and encapsulation efficiency
and an increase in particle size of microspheres. When the volume of the external phase of the secondary emulsion was increased,
a decrease in yield, particle size, and encapsulation efficiency was observed. Microspheres with good batch-to-batch reproducibility
could be produced. Scanning electron microscopic study indicated that microspheres existed as aggregates. |
| |
| Keywords: | 5-fluorouracil microspheres PLGA microspheres optimization |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
