Permeation Studies of Indomethacin from Different Emulsions for Nasal Delivery and Their Possible Anti-Inflammatory Effects |
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Authors: | H Ye?im Karasulu Z Evren ?anal Sumru Sözer Tamer Güneri Gökhan Ertan |
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Institution: | (1) Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ege, 35100 Bornova, Izmir, Turkey;(2) Department of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Ege, 35100 Bornova, Izmir, Turkey |
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Abstract: | The purpose of this research was to develop an emulsion formulation of indomethacin (IND) suitable for nasal delivery. IND
was incorporated into the oil phases of oil in water (O/W) and water in oil (W/O) emulsions. For this purpose, different emulsifying
agents (Tween 80, Span 80 and Brij 58) were used in two emulsion formulations. When the effects of several synthetic membranes
(nylon, cellulose, cellulose nitrate) were compared with the sheep nasal mucosa, the cellulose membrane and sheep nasal mucosa
showed similar permeation properties for O/W emulsion (P > 0.05). To examine the absorption characteristics of IND, the anti-inflammatory properties of intravenous solution of IND,
intranasal O/W emulsions of IND (with or without enhancers) and intranasal solution of IND (IND-Sol) were investigated in
rats with carrageenan-induced paw edema. When citric acid was added to the nasal emulsion, the anti-inflammatory activity
was similar to that of intravenous solution (P > 0.05). Finally, it was concluded that, intranasal administration of IND emulsion with citric acid may be considered as
an alternative to intravenous and per oral administrations of IND to overcome their adverse effects. |
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Keywords: | anti-inflammatory activity indomethacin nasal emulsion penetration enhancer |
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