Artemisia arborescens L essential oil loaded beads: Preparation and characterization |
| |
Authors: | Francesco Lai Giuseppe Loy Maria Manconi Maria Letizia Manca Anna Maria Fadda |
| |
Institution: | (1) Dipartimento Farmaco Chimico Tecnologico, Università di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy |
| |
Abstract: | The purpose of this work was to prepare sodium alginate beads as a device for the controlled release of essential oil for
oral administration as an antiviral agent. Different formulations were prepared with sodium alginate as a natural polymer
and calcium chloride or glutaraldehyde as a cross-linking agent. Loading capacities of between 86% and 100% were obtained
in freshly prepared beads by changing exposure time to the cross-linking agent. Drying of the calcium alginate beads caused
only a slight decrease in the loading efficiency. The surface morphology of the different bead formulations were studied using
scanning electron microscopy (SEM). Stability studies over a 3-month period showed that glutaraldehyde reacted with some components
ofArtemisia arborescens L essential oil, changing its composition. Calcium alginate beads showed an in vitro controlled release of the essential
oil for the investigated 24 hours, while the use of glutaraldehyde as a cross-linking agent was found not appropriate because
of the interactions with azulene derivatives and the low degree of matrix cross-linkage.
Published: August 24, 2007 |
| |
Keywords: | Essential oil antiviral controlled release Artemisia arborescens beads sodium alginate |
本文献已被 PubMed SpringerLink 等数据库收录! |