Dissolution Improvement of Electrospun Nanofiber-Based Solid Dispersions for Acetaminophen |
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Authors: | Deng-Guang Yu Christopher Branford-White Kenneth White Xue-Lian Li Li-Min Zhu |
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Institution: | (1) College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Songjiang District, Shanghai, 201620, China;(2) Institute for Health Research and Policy, London Metropolitan University, London, N7 8DB, UK; |
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Abstract: | The objective of the present investigation was to prepare novel solid dispersions (SDs) of poorly water-soluble drugs with
special microstructural characteristics using electrospinning process. With the hydrophilic polymer polyvinylpyrrolidone as
the filament-forming polymer and acetaminophen (APAP) as the poorly water-soluble drug model, SDs having a continuous web
structure, and in the form of non-woven nanofiber membranes, were successfully prepared. The electrospun nanofiber-based SDs
were compared with those prepared from three traditional SD processes such as freeze-drying, vacuum drying, and heating drying.
The surface morphologies, the drug physical status, and the drug-polymer interactions were investigated by scanning electron
microscopy, differential scanning calorimetry, X-ray diffraction, and attenuated total reflectance Fourier transform infrared.
In vitro dissolution tests demonstrated that the electrospun nanofibers released 93.8% of the APAP content in the first 2 minutes
and that the dissolution rates of APAP from the different SDs had the following order: electrospun membrane > vacuum-dried
membrane ≈ freeze-dried membrane > heat-dried membrane. Electrospun nanofiber-based SDs showed markedly better dissolution-improving
effects than the other SDs, mainly due to their huge surface area, high porosity resulting from web structure, and the more
homogeneous distribution of APAP in the nanofiber matrix. |
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