Supercritical Extraction of Carotenoids from Rosa canina L. Hips and their Formulation with β-Cyclodextrin |
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Authors: | R Tozzi N Mulinacci K Storlikken I Pasquali F F Vincieri R Bettini |
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Institution: | (1) Department of Pharmacy, University of Parma, Viale G.P. Usberti 27/A, 43100 Parma, Italy;(2) Department of Pharmaceutical Sciences, University of Florence, Florence, Italy |
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Abstract: | The purpose of this research was to preliminary assess the suitability of a new method for the preparation of a solid formulation
in form of powder composed by β-cyclodextrin and the supercritical extract of Rosa canina hips. The method implies the extraction of carotenoids, in particular β-carotene, from freeze dried fruits of R. canina with supercritical CO2 at 70 °C and 300 bar, in the presence of varying quantity of ethanol as entrainer. The obtained supercritical solution is
then expanded at ambient conditions into an aqueous solution of β-cyclodextrin to favour the interaction between β-cyclodextrin
and the lipophilic components of the extract. β-carotene solubility (mole fraction) in supercritical CO2 or in supercritical CO2/ethanol mixtures were in the order of 1 10−7. The β-carotene extracted from R. canina fruits (nearly 10 μg/g of dry matrix), interacts almost quantitatively with β-cyclodextrin affording a solid phase, which
presents a low apparent solubility in water. Finally the interaction with β-cyclodextrin results in a higher concentration
of the β-carotene trans- form relative to the cis- form in the extracted product when collected in an aqueous solution of β-cyclodextrin with respect to the extract in n-hexane. |
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Keywords: | β -carotene β -cyclodextrin interaction compound Rosa canina supercritical CO2 |
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