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Influx of γ-Aminobutyric Acid and α-Aminoisobutyric Acid into Mouse Cerebrum Slices Incubated in a Pyruvate Medium with or without Added Glucose or Glucose Analogues Compared with Influx from a Glucose Medium |
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| Authors: | Stephen R Cohen |
| Institution: | New York State Institute for Basic Research in Mental Retardation, Staten Island, New York 10314, U.S.A. |
| Abstract: | Concentrative influx of γ-aminobutyric acid (GABA) and α-aminoisobutyric acid (AIB) into incubated mouse cerebrum slices is decreased when pyruvate is substituted for glucose. Influx of GABA from pyruvate medium is not increased by presence of glucose, 2-deoxy-d -glucose (2-DOG), or 3-O-methyl-d -glucose (3-O-MeG). Influx of AIB is restored to the rate from glucose medium if 2-DOG is present initially, but is not restored if 2-DOG is added with AIB. Influx is not restored if 3-O-MeG is present initially, but is restored if 3-O-MeG is added with AIB. Influx is restored if glucose is present initially or is added with AIB. |
| Keywords: | Brain Slices—Transport—Influx—Amino acids—Pyruvate—Glucose Cohen S R Influx of γ-aminobutyric acid and a-aminoisobutyric acid into mouse cerebrum slices incubated in a pyruvate medium with or without added glucose or glucose analogues compared with influx from a glucose medium J Neurochem 35 1008–1012 (1980) |