Postnatal Changes in the Activity Ratio of Specific and Nonspecific Cholinesterases from Neuronal Perikarya |
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| Authors: | Enrique L M Ochoa Alicia Brusco Victor P Idoyaga-Vargas† Hector Carminatti† |
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| Institution: | Institute de Biologiu Celular, Facultud de Medicinu, Buenos Aires, Argentina;Instituto de Investigaciones Bioquimicas "Fundacion Cumpomur" und Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina |
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| Abstract: | Abstract: A soluble fraction from rat brain neuronal perikarya was shown to contain both the specific and nonspecific forms of the enzyme acetylcholines-terase (EC's 3.1.1.7. and 3.1.1.8., respectively). The ratio of the enzyme activities varied along the course of brain development: the nonspecific form being predominant from 1 to 15 days of age and the specific one showing the pattern of rising activity from day 15 onward. We suggest a possible relationship between this changing in cholinesterase activities and the establishment of synapses within the rat cerebral cortex. |
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| Keywords: | Acetylcholinesterase Neurons Postnatal development |
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