Prostaglandin E2 inhibits Paracoccidioides brasiliensis killing by human monocytes |
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| Authors: | Bordon Ana Paula Dias-Melicio Luciane Alarcão Acorci Michele Janegitz Calvi Sueli Aparecida Serrão Peraçoli Maria Terezinha Victoriano de Campos Soares Angela Maria |
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| Institution: | 1. NanoBio High-Tech Materials Research Center, Department of Biological Engineering, Inha University, 100 Inha-ro, Incheon 22212, Republic of Korea;2. Chungcheong Division Reliability Center, Korea Confomity Laboratories, Yuseong-gu, Daejeon, 34027, Republic of Korea;3. Research Group of Consumer Safety, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Korea |
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| Abstract: | Human monocytes lacked fungicidal activity against high virulence strain of Paracoccidioides brasiliensis, even after IFN-gamma activation. However, monocytes treated with indomethacin exhibited an effective killing against this fungus, suggesting a role of prostaglandin E2 (PGE2) in the inhibition process. Thus, the purpose of this work was to determine whether the effect of PGE2 in fungicidal activity was related with decrease on H(2)O(2) release, the metabolite involved in P. brasiliensis killing, and changes in the levels of TNF-alpha, IL-6 and IL-10. Human monocytes challenged with the fungus produced high PGE2 levels, which in turn inhibited the fungicidal activity of these cells by reducing H(2)O(2) and TNF-alpha production. |
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