Development of small-molecule inhibitors against hantaviruses |
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| Institution: | 1. College of Life Sciences, Hebei Agricultural University, Baoding, China;2. Research Center of Chinese Jujube, Hebei Agricultural University, Baoding, China;3. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, China;1. Laboratory of Molecular Immunovirology, General Biology Department, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil;2. Chemistry Department, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil;3. Instituto Federal Do Norte de Minas Gerais - Campus Diamantina, Diamantina, Minas Gerais, Brazil;4. Instituto Federal de Minas Gerais (IFMG), Campus Ouro Branco, Rua Afonso Ouro Branco, Minas Gerais, Brazil;5. Laboratory of Microbiology, Microbiology Department, Federal University of Viçosa, Brazil;1. College of Life Sciences, Hebei Agricultural University, Baoding, China;2. Research Center of Chinese Jujube, Hebei Agricultural University, Baoding, China;3. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, China;1. Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No.35, Keyan Road, Zhunan Town, Miaoli, 35053, Taiwan, ROC;2. Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No.35, Keyan Road, Zhunan Town, Miaoli, 35053, Taiwan, ROC;3. Department of Life Sciences, National Central University, Jhongli, Taiwan, ROC;1. Laboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR7257 CNRS, Parc Scientifique de Luminy, Aix-Marseille Université, Marseille, France;2. Molecular Basis of Viral Pathogenicity, International Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, Université Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France |
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| Abstract: | Hantavirus (HV), a pathogen of animal infectious diseases that poses a threat to humans, has attracted extensive attention. Clinically, HV can cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), between which HFRS is mostly in Eurasia, and HPS is mostly in the Americas. This paper reviews the research progress of small-molecule inhibitors of HV. |
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| Keywords: | Hantavirus Small-molecule compound Peptide |
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