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Role of Nod2 in the development of Crohn's disease |
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| Authors: | Soichiro Yamamoto Xiaojing Ma |
| Institution: | aDepartment of Microbiology and Immunology, Weill Medical College of Cornell University 1300 York Avenue, New York, NY 10021, USA |
| Abstract: | Crohn's Disease (CD) is caused by a loss of the regulatory capacity of the immune apparatus. Nod2 is an intracellular bacterial sensor and its mutations are associated with the development of CD. Here we summarize recent and controversial findings about the role of the Nod2 mutants in the disease process. |
| Keywords: | Crohn's disease Inflammation Homeostasis Interleukin-10 Monocytes Macrophages Nod2 1007fs R702W G908R Interleukin-12 Interleukin-23 Mucosal immunity TLR Commensals |
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