| 人干细胞实验动物嵌合体模型的研究进展 |
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| 引用本文： | 周文君,;张连峰.人干细胞实验动物嵌合体模型的研究进展[J].中国实验动物学杂志,2007(11):I0014-I0016. |
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| 作者姓名： | 周文君 ;张连峰 |
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| 作者单位： | [1]中国医学科学院实验动物研究所,中国协和医科大学比较医学研究中心,北京100021 |
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| 摘 要： | 动物模型是疾病研究、发病机制、药物治疗的必要工具,目前一些困扰人类健康的重大疾病如艾滋病、乙型肝炎等因为还没有能反映人类疾病发病机理的理想动物模型。人干细胞是能在体外长期培养的、高度未分化的全能细胞系,亚全能细胞系和分化的干细胞等。如果能将人的干细胞成功移植入实验动物体内形成人源化嵌合体动物,有希望为艾滋病、肝炎等的研究制备适当的模型。人类干细胞在动物中的移植研究中主要的实验动物是绵羊,小鼠等,本文介绍了人干细胞在动物体内移植的研究进展。
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| 关 键 词： | 人干细胞 实验动物 嵌合体 模型 动物 |
Development on Model Research of Human Stem Cells Chimerism |
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| Institution: | ZHOU Wen-jun, ZHANG Lian-feng (Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China) |
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| Abstract: | Animal model is an indispensable way for diseases research, pathology mechanism investigate, clinic medicine therapy experiments. At present, HIV, HBV still damage human healthy seriously because there are no proper animal models infected by such human viruses to research procedure of diseases which are causes by HIV and HBV. If human stem cells, which grow and differentiate outside of human bodies, were engrafted into laboratory animals＇ bodies to form chimerism successfully, human would culture animal models AIDS and other serious diseases to do more deep research and make out appreciate therapy protocols. Now sheep, mice are chief laboratory animals for human stem cells engraftment, we will introduce the developmental status on human stem cells engraftment. |
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| Keywords: | Human stem cell Laboratory animal Chimerism Model animal |
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