中国被毛孢和蝙蝠蛾拟青霉小鼠免疫功能调节作用的比较

目的观察中国被毛孢和蝙蝠蛾拟青霉对小鼠免疫功能的影响。方法分别给予中国被毛孢和蝙蝠蛾拟青霉后，测定观察对小鼠碳粒廓清功能、迟发性变态反应、溶血素抗体、淋巴细胞增殖和NK细胞活性等的影响。结果3．0g／kg中国被毛孢和蝙蝠蛾拟青霉可显著提高小鼠吞噬指数和半数溶血值（P〈0．01）、显著提高T、B淋巴细胞增殖能力（P〈0．01，P〈0．05）、显著提高NK细胞活性（P〈0．05），0．5～1．5g／kg中国被毛孢都能显著抑制小鼠耳廓肿胀（P〈0．01，P〈0．05），同时还能抑制脾脏和胸腺增大（P〈0．01，P〈0．05）。结论中国被毛孢和蝙蝠蛾拟青霉均具有免疫调节作用，而中国被毛孢免疫抑制及增强天然免疫系统作用要优于蝙蝠蛾拟青霉，而对适应性免疫系统增强作用蝙蝠蛾拟青霉优于中国被毛孢。

Comparison and Characterization on Immunomodulatory Function of Hirsutella sinensis and Paecilomyces hepiali in Mice

Objective Compare with the immunomodulatory function by Hirsutella sinensis and Paecilomyces hepiali in vivo. Method After the mice were administrated by Hirsutella sinensis and Paecilomyces hepiali. Observed carbon particle clearance function, delayed type hypersensitivity, hemolytic antibody, lymphocyte proliferation and NK cell activity in mice, and Cordyceps sinensis as a positive control. Result 3.0g/kg Hirsutella sinensis and Paecilomyces hepiali can significantly improve the phagocyte index and half of hemolysis value （ P 〈 0. 01 ）. 3.0 g/kg Hirsutella sinensis and Paecilomyces hepiali can significantly improve the T, B lymphocyte proliferation （ P 〈 0.01, P 〈 0. 05 ）. 3.0 g/kg Hirsutella sinensis can significantly enhance the activity of NK cells （ P 〈 0. 05 ）. 0. 5 ~ 1.5 g/kg Hirsutella sinensis can significantly inhibit the ear edema in mice （P 〈 0. 01, P 〈 0. 05 ） , at the same time 1.5 g/kg Hirsutella sinensis can inhibit the spleen and thymus increases（P 〈 0, 01, P 〈 0.05 ）. Conclusion Hirsutella sinensis and Paecilomyces hepiali have Immunomodulatory effects. Hirsutella sinensis. The Hirsutella sinensis were better than Paecilomyces hepiali in immunosuppression and enhance the role of the innate immune system. Paecilomyees hepiali were better than the Hirsutellasinensis in enhanced adaptive immune system.