| 静脉桥狭窄家兔动物模型的建立 |
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| 引用本文： | 唐秀杰,景小勇,王春燕,吴清玉.静脉桥狭窄家兔动物模型的建立[J].中国实验动物学杂志,2010(8):53-55,82. |
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| 作者姓名： | 唐秀杰 景小勇 王春燕 吴清玉 |
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| 作者单位： | 清华大学第一附属医院心脏中心心外科,北京市100016 |
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| 基金项目： | 清华大学裕元基金（20240000578） |
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| 摘 要： | 目的建立冠心病冠状动脉旁路移植术后移植静脉桥狭窄的动物模型。方法取3.0～3.5 kg普通新西兰兔8只,取同侧颈外静脉与颈总动脉进行端端吻合,吻合时采用间断缝合的方法。结果术后2周、4周取下静脉桥及对侧颈外静脉,光镜下见静脉桥新生内膜形成,中膜增厚,弹力纤维减少;胶原纤维不均匀性增厚。结论本模型能反映冠状动脉旁路移植术后静脉桥狭窄的情况,可满意模拟人冠状动脉旁路移植术后大隐静脉桥的病理变化。
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| 关 键 词： | 模型 动物 静脉桥狭窄 兔 |
Construction of a Rabbit Model of Vein Graft Stenosis |
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| TANG Xiu-jie,JING Xiao-yong,WANG Chun-yan,WU Qing-yu.Construction of a Rabbit Model of Vein Graft Stenosis[J].Chinese Journal of Laboratory Animal Science,2010(8):53-55,82. |
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| Authors: | TANG Xiu-jie JING Xiao-yong WANG Chun-yan WU Qing-yu |
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| Institution: | (Heart Center of First Hospital of Tsinghua University,Beijing 100016,China) |
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| Abstract: | Objective To construct a rabbit model of vein graft simulating the pathology of human saphenous vein graft.Methods The studies were performed on New Zealand white rabbits（8 cases）,weighing 3.0 ～ 3.5 kg.Every rabbit’s unilateral jugular vein was anastomosed with common carotid artery end to end with interrupted suture.Results After 2 weeks and 4 weeks,samples of tissues were harvested and examined under a light microscope.The neointimal and medial layers showed significant hyperplasia compared with the normal jugular vein.Conclusion The method of anastomosis is successful and the model can mimic the pathology of human saphenous vein graft. |
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| Keywords: | Animal Model Vein graft stenosis Rabbit |
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