高脂血症恒河猴血清RETN与血脂的相关性分析

目的探讨高脂血症恒河猴血清抵抗素（RETN）水平与血脂的相关性。方法高脂血症恒河猴和健康恒河猴各8只,分别为实验组及对照组,测定其空腹血清RETN、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）,分析高脂血症恒河猴血清RETN水平与血脂的关系。结果实验组的血清RETN水平、TC、LDL-C显著高于对照组（P〈0.05）,实验组TG较对照组显著降低（P〈0.05）;两组HDL-C差异不显著（P〉0.05）。相关分析显示,血清RETN与TC、LDL-C正相关,与TG负相关,与HDL-C无相关性。结论高脂血症恒河猴血清RETN水平与血脂存在相关性,可为人类高脂血症研究提供实验数据。

Correlation Analysis between Serum Concentration of RETN and Lipids of Hyperlipidemia in Rhesus Monkey

Objective To explore the correlation between serum concentration of resistin and lipid of hyperlipidemia in Rhesus monkey. Methods The study included 8 Rhesus monkeys with hyperlipidemia and 8 healthy, were experimental group and control group. Their fast serum resistin, total cholesterol（TC） , triglyceride （ TG ） , high- density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterol（ LDL-C ）were measured overnight fast. The correlation between serum concentration of resistin and lipid was explored. Results The serum resistin, TC and LDL-C in the experimental group was significantly higher than those in the control group（ P 〈 0. 05 ）, eompared with control group, TG had decreased significantly in the experimental group（ P 〈 0. 05 ） , no significant difference between these two groups in HDL-C（ P 〉0. 05 ）. The correlation analysis showed the serum eoneentration of resistin was positively correlated with TC and LDL-C, negatively correlated with TG, and no correlation was shown with HDL-C. Conclusions The serum concentration of resistin had correlation with lipid in Rhesus monkey with byperlipidemia, and to provide experimental data for the study of human hyperlipidemia.