| 压力应激动物模型在肿瘤中的应用和研究现状 |
| |
| 引用本文： | 王炎,李琦.压力应激动物模型在肿瘤中的应用和研究现状[J].中国实验动物学杂志,2013(9):75-79. |
| |
| 作者姓名： | 王炎 李琦 |
| |
| 作者单位： | [1]上海中医药大学附属曙光医院肿瘤科,上海201203 [2]上海中医药大学附属龙华医院中医肿瘤研究所,上海200032 |
| |
| 基金项目： | 国家自然科学基金青年项目（81001594）;上海市自然科学基金（09ZR1428500）. |
| |
| 摘 要： | 目的就各类压力应激荷瘤动物模型的造模方法进行综述，对其特点进行评述，并分析了压力应激在肿瘤发生发展中的作用机制。方法应用计算机检索PubMed数据库（2000／2013），以“stress，animalmodel，tumor”为检索词；检索中国知识资源总库（2000～2013）、重庆维普数据库（2000～2013）、万方数据库（2000～2013）三大中文期刊数据库，以“应激，动物模型，肿瘤”为检索词。文章所述内容需与应激动物模型的建立、应用、评价，及压力应激与肿瘤的关系等方面研究密切相关，排除重复性研究。结果共收集596篇关于应激动物模型的文献，中文156篇，英文440篇。阅读标题和摘要进行初筛，排除发表时间较早、重复及类似的研究，纳入30篇符合标准的文献。结论压力应激与肿瘤研究领域为进一步从抗焦虑、抑郁等角度筛选抗肿瘤药物提供参考。
|
| 关 键 词： | 应激 模型 动物 肿瘤 |
The application and research status with cancer on stress model in tumor-bearing animal |
| |
| WANG Yan,LI Qi.The application and research status with cancer on stress model in tumor-bearing animal[J].Chinese Journal of Laboratory Animal Science,2013(9):75-79. |
| |
| Authors: | WANG Yan LI Qi |
| |
| Institution: | l Department of Medical Oncology, Shuguang I-Iospital, Shanghai University of Traditional Chinese Medicine, Shanghai,201203 China; 2. Tumor Institute of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China) |
| |
| Abstract: | Objective To review the methods of stress model in tumor-bearing animal, and to analyze the perspective of the stress in tumor development role mechanism. Methods A computer-based online search was performed using key words of ＂stress, animal model, murine, and evaluate＂ for documents on VIP and PuMed from 2000 to 2013. Repetitive papers were excluded. Results A total of 596 documents were collected, including 156 in Chinese and 440 in English. By reading titles and abstract, 30 papers were included in the final analysis. Conclusion It is provided a new approach to further explore the stress in tumor pathogenesis mechanisms, and screening antitumor drugs. |
| |
| Keywords: | Stress Model animal Tumor |
| 本文献已被 维普 等数据库收录！ |
