| 轴突生长抑制因子重组疫苗预防免疫减轻阿尔茨海默症模型小鼠行为学损伤 |
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| 引用本文： | 张玲玲,马全红,杨武林,刘颖,马春梅,黄澜,徐艳峰,朱华,邓巍,肖志成,秦川.轴突生长抑制因子重组疫苗预防免疫减轻阿尔茨海默症模型小鼠行为学损伤[J].中国实验动物学杂志,2011(6):60-63. |
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| 作者姓名： | 张玲玲 马全红 杨武林 刘颖 马春梅 黄澜 徐艳峰 朱华 邓巍 肖志成 秦川 |
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| 作者单位： | [1]北京协和医学院比较医学中心,中国医学科学院医学实验动物研究所,卫生部人类疾病比较医学重点实验室；北京协和医学院比较医学中心,中国医学科学院医学实验动物研究所,国家中医药管理局人类疾病动物模型三级实验室,北京100021 [2]苏州大学神经科学研究所,苏州215123 [3]蒙纳士大学免疫干细胞实验室,维多利亚,澳大利亚3800 [4]昆明医学院分子临床医学研究所,昆明650031 |
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| 摘 要： | 目的研究轴突生长抑制因子重组DNA疫苗对转基因阿尔茨海默症小鼠的预防治疗。方法轴突生长抑制因子重组DNA疫苗肌肉注射APP/PS1双转阿尔茨海默症模型小鼠。设野生对照组、模型对照组、空载体对照组、疫苗组。水迷宫实验检测小鼠行为学差别。结果疫苗组小鼠在4.5月龄水迷宫实验中学习记忆能力较模型对照及空载体对照组有显著差异（P〈0.05）。结论肌肉注射轴突生长抑制因子DNA重组疫苗能够改善小鼠学习记忆能力。
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| 关 键 词： | 轴突生长抑制因子 阿尔茨海默症 重组疫苗 |
Vaccine against Neurite Outgrowth Inhibitors Attenuates Behavioral Impairments in an Alzheimer＇s Mouse Model |
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| ZHANG Ling-ling,MA Quan-hong,YANG Wu-lin,LIU Ying,MA Chun-mei,HUANG Lan,XU Yan-feng,ZHU Hua,DENG Wei,XIAO Zhi-cheng,QIN Chuan.Vaccine against Neurite Outgrowth Inhibitors Attenuates Behavioral Impairments in an Alzheimer＇s Mouse Model[J].Chinese Journal of Laboratory Animal Science,2011(6):60-63. |
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| Authors: | ZHANG Ling-ling MA Quan-hong YANG Wu-lin LIU Ying MA Chun-mei HUANG Lan XU Yan-feng ZHU Hua DENG Wei XIAO Zhi-cheng QIN Chuan |
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| Institution: | 1.Key Laboratory of Human Disease Animal Model,State Administration of Traditional Chinese Medicine ＆ Key Laboratory of Human Disease Comparative Medicine,Ministry of Health,Institute of Laboratory Animal Science, Comparative Medical Center,Peking Union Medical College ＆ Chinese Academy of Medical Sciences,Beijing, 100021,China;2.Institute of Neuroscience,Soochow University,215123,China;3.Monash Immunology and Stem Cell Lab oratories,Monash University,Clayton,Victoria,3800,Australia;4.Institute of Molecular and Clinical Medicine,Kunming Medical College,650031,China) |
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| Abstract: | Objective To study the preventive immunity effects of myelin-associated neurite outgrowth inhibitors（NGI） recombinant DNA vaccine on APP/PS1 co-transgenic Alzheimer＇s model mice.Methods The recombinant DNA vaccine was intramuscularly injected in APP/PS1 co-transgenic mice.Wild type（WT） group,blank group and blank vector group as control.The behavioral tests were examined by the Morris Water Maze.Result The behavioral impairments of vaccine group were significantly approved in Morris Water Maze（MWM）（P〈0.05）.Conclusion Intramuscularly injected with NGI DNA vaccine attenuated behavioral impairment in a co-transgenic mouse model of Alzheimer＇s disease. |
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| Keywords: | Neurite outgrowth inhibitors Alzheimer disease Recombinant vaccine |
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