| 肝素结合性表皮生长因子在心肌重塑中的作用 |
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| 引用本文： | 邵海涛,张连峰.肝素结合性表皮生长因子在心肌重塑中的作用[J].中国实验动物学杂志,2011(6):80-84. |
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| 作者姓名： | 邵海涛 张连峰 |
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| 作者单位： | 中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室国家中医药管理局人类疾病动物模型三级实验室,北京100021 |
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| 基金项目： | 卫生部行业基金 实验动物和人类疾病动物模型资源扩展（200802036）; 十一五新药专项支持（2009ZX09501-026） |
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| 摘 要： | 肝素结合性表皮生长因子（HB-EGF）是表皮生长因子家族成员之一。HB-EGF是多种细胞的有丝分裂原,参与一系列生理和病理过程,包括心肌细胞肥大,成纤维细胞增生,胶原纤维表达增多,是心肌重塑发生发展过程中的一个重要生长因子。本文综述了HB-EGF在心肌重塑过程中的研究进展。
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| 关 键 词： | 肝素结合性表皮生长因子 心脏 重塑 纤维化 |
The roles of Heparin-binding Epidermal Growth Factor-like Growth Factor in Myocardium Remodeling |
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| SHAO Hai-tao,ZHANG Lian-feng.The roles of Heparin-binding Epidermal Growth Factor-like Growth Factor in Myocardium Remodeling[J].Chinese Journal of Laboratory Animal Science,2011(6):80-84. |
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| Authors: | SHAO Hai-tao ZHANG Lian-feng |
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| Institution: | (Key Laboratory of Human Disease Comparative Medicine,Ministry of Heath,Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences ＆ Peking Union Medical College,Human Disease Animal Models Level-3 Laboratory of State Administration of Traditional Chinese Medicine,,Beijing 100021,China) |
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| Abstract: | Heparin-binding epidermal growth factor-like growth factor（HB-EGF） is a member of the epidermal growth factor（EGF） family.HB-EGF is a potent mitogen for a number of cell types and has been implicated in a variety of physiological and pathological processes,including myocardial remodeling,fibroblast hyperplasia and collagen expression.In this review,the HB-EGF in myocardial remodeling was summarized. |
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| Keywords: | HB-EGF Heart Remodeling Fibrosis |
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