乌司他丁联合血必净对内毒素致绵羊多脏器功能障碍综合征的防治研究

目的探讨乌司他丁（UTI）联合血必净（XBJ）对内毒素（LPS）致多脏器功能障碍综合征（MODS）的防治作用。方法将50只绵羊随机分为对照组（A组）、模型组（B组）、乌司他丁组（C组）、血必净组（D组）和乌司他丁＋血必净组（E组）,每组10只。利用LPS建立MODS模型,并以UTI、XBJ和UTI＋XBJ进行防治。观察各组的体征表现,测定不同时点各组的血气、血常规、血清生化指标的改变。结果 UTI＋XBJ组绵羊的体征表现明显减轻、死亡率明显降低,PaO2、生化指标和白细胞数目得到了有效的控制。结论乌司他丁联合血必净较单独应用能明显改善LPS诱导的MODS动物体征表现、降低死亡率,对肺脏、肝脏和肾脏等多脏器损伤具有良好的防治作用。

Study on Prevention and Cure of Ulinastatin Combined with XUEBIJING in Multiple Organ Dysfunction Syndrome Induced by Lipopolysaccharide in Sheep

Objective To investigate prevention and cure effect of Ulinastatin（UTI） combined with XUEBIJING（XBJ） on multiple organ dysfunction syndrome（MODS） induced by lip polysaccharide（LPS） in sheep.Methods 50 sheep were randomly separated into 5 groups ： the control（Group A）,model group（Group B）,UTI group（Group C）,XBJ group（Group D） and UTI ＋ XBJ group（Group E）,10 sheep each group.The MODS model was established by LPS in sheep.It was prevented and cured by UTI,XBJ and UTI ＋ XBJ.Then the physical sign appearance was observed and the indexes of blood gas,blood routine and blood biochemistry were determined in each group.Results The sheep in UTI＋XBJ group,the physical sign appearance was obviously alleviative,the death rate was markedly degraded.Arterial oxygen pressure（PaO2）,the biochemical indexes and the number of WBC was regulated efficiently.Conclusion UTI ＋ XBJ could improve obviously physical sign appearance,degrade the death rate and it had favourable preventive and therapeutic effect on damage in multiple organ.