不同影响因素对热原实验中兔筛选的影响

目的分析不同影响因素对新西兰兔的初次筛选合格率、二次筛选合格率的影响。方法根据2005版《中国药典》进行测定。结果初次筛选结果中,不同季节、体重值、性别、湿度新西兰兔的筛选率都有显著性差异,筛选时间在7～9月、体重值为1.7～2.0 kg、雄性的新西兰兔、在湿度为61～70%的条件下初次筛选率较高;在二次筛选结果中,不同季节、室温、湿度条件下新西兰兔的筛选率都有显著性差异,筛选时间在1～3月、在室温为22.1～23.0℃、湿度为61～70%的条件下新西兰兔的二次筛选率较高。结论在不同影响因素的条件下,新西兰兔的初次筛选合格率、二次筛选合格率均受到影响。

Effect on the Screening of Rabbits by Different Factors in Pyrogen Test

Objective To analyze the influence to the 1st screening eligible rate and 2nd screening eligible rate of New Zealand Rabbits according to different factors.Methods Mensurating by Chinese Medicine Dictionary（edition of 2005）.Results The consequence of the 1st screening eligible shows the remarkable difference in the different seasons,different body weights,different sexes and different humidities of New Zealand Rabbits.The higher screening eligible rate of 1.7~2.0 kg,male New Zealand Rabbits from July to September,the suitable humidity is 61~70%;The consequence of the 2nd screening eligible shows the remarkable difference in the different seasons,room temprature and humidity of New Zealand Rabbits.The higher screening eligible rate occurs from Jan.to Mar.,the suitable room temperature is 22.1~23.0℃ and humidity is 61~70%.Conclusions Under different factors,the first screening eligible rate and second screening eligible rate of New Zealand Rabbits will be influenced.