恒河猴正常子宫及妊娠后期胎儿的MRI研究

目的研究恒河猴正常子宫及妊娠后期胎儿的MRI表现。方法对3只未妊娠和3只妊娠135d的恒河猴分别进行磁共振成像（MRI）扫描,观察子宫及胎儿的影像学特点。结果未妊娠恒河猴的子宫T1WI冠状位呈椭圆形,子宫体各层呈中等信号,矢状位呈葫芦形。在T2WI上,冠状位显示宫体可见2～3层不同的信号带,在矢状位子宫体肌层的信号高于子宫颈,信号的移行区是体颈的交界处。妊娠恒河猴的子宫肌层变薄,胎盘及胎儿的脑、脊柱、肝、肺等结构显示清楚。结论MRI能很好地显示恒河猴子宫的形态、胎儿各部分的结构。对人畸形胎儿的产前诊断有一定的参考价值。

Magnetic Resonance Imaging of Normal Uterus and Fetal Development during Late Stage of Pregnancy in Rhesus Monkeys

Objective To investigate the MRI features of normal uterus and fetal development during late stage of pregnancy in rhesus monkeys. Methods Magnetic resonance imaging （MRI） at 1.5 Tesla was performed in 3 adult female rhesus and 3 rhesus at 135 days of pregnancy. The MRI signal intensity and anatomic structure of normal uterus and characteristics of fetuses were retrospectively evaluated. Results On coronal T1 weighted images, the normal uterus wall showed moderate signal intensity with a elliptic shape. While on sagital view, the uteri appeared a cucurbit shape on T2 weighted images （T2WI）, and three layers of the structure of uterus wall depicting different signals were noticed. On sagital section （T2WI）, the signal intensity of muscular wall of uterus body was slightly higher than that of cervix, the signal transition zone was at the junction zone of the uterine body and cervix. During late stage of pregnancy, the uteri were enlarged markedly but the uterus wall was substantially thinned. The placenta, brain, spinal cord, liver and lung of the fetus were well demonstrated. Conclusion MRI imaging can well demonstrate the shape, size and wall layers of uterus and anatomic structures of the fetus. It is a noninvasive approach for evaluating the female genital organ changes and may be helpful in detection of possible abnormal development of fetus in humans.