| 帕金森病模型研究进展 |
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| 引用本文： | 邓兴力,;刘如恩,;雷德强,;冯忠堂.帕金森病模型研究进展[J].中国实验动物学杂志,2008(7):63-67. |
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| 作者姓名： | 邓兴力 ;刘如恩 ;雷德强 ;冯忠堂 |
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| 作者单位： | [1]昆明医学院第一附属医院神经外科,昆明650032; [2]中日友好医院神经外科,北京100029; [3]华中科技大学同济医学院附属协和医院神经外科,武汉430022 |
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| 基金项目： | 国家自然科学基金（30672151）;中日友好医院重点科研基金（20052016）. |
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| 摘 要： | 帕金森病（Parkinson’s disease，PD）是一种常见于中老年的神经退行性疾病，其特征性的病理改变为黑质纹状体多巴胺能神经元选择性缺失以及胞浆内涵物Lewy小体的形成。PD的发病机制目前尚不清楚，但已经明确环境因素和遗传因素在PD的发病中起重要作用。为阐明PD的病理生理机制，进一步探索新的治疗手段，迫切需要与PD密切相似的模型。本文将就目前发展的各种PD模型做一综述。
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| 关 键 词： | 帕金森病 模型 Lewy小体 |
Recent Progress in Models of Parkinson＇s Disease |
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| Institution: | DENG Xing-li , LIU Ru-en , LEI De-qiang , FENG Zhong-tang( 1. Department of Neurosurgery, 1^st Affiliated Hospital of Kunming Medical College, Kunming 650032 ; 2. Department of Neurosurgery, China-Japan Friendship Hospital, Beijing 100029; 3. Department of Neurosurgery, Affiliated Union Hospital of Tongji Medical College, Huazhong University of Science ＆ Technology, Wuhan 430022) |
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| Abstract: | Parkinson＇s disease （PD） is a progressive neurodegenerative disorder that is primarily characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway. The pathology of PD is typified by the presence of cytoplasmic inclusions （Lewy bodies ） containing a-synuclein and ubiquitin. The pathogenesis of PD is not completely understood but environmental and genetic factors are thought to play important roles. To understand the pathophysiology of PD, and to develop novel therapies for improved symptomatic management, it is important to have relevant disease models. In this review, we summarize the available in vivo and in vitro models of PD and discuss their value. |
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| Keywords: | Parkinson＇s disease （PD） Model Lewy bodies |
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