Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice

Authors:	Qinling Pan Tingfeng Qin Yuan Gao Shaojian Li Danjie Li Miao Peng Hening Zhai Geyang Xu

Institution:	1. Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China;2. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China;3. Endoscopy Center, The First Affiliated Hospital of Jinan University, 613 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510630, China

Abstract:

Keywords:	ACC acetyl-CoA carboxylase Ad-GFP adenovirus-mediated green fluorescent protein Ad-S6K1 adenovirus-mediated p70 ribosomal protein subunit 6 kinase 1 AMPK AMP-activated protein kinase DGAT acyl CoA:diacylglycerol transferase DIO diet-induced obese DMSO dimethyl sulfoxide FAS fatty acid synthase GPAT glycerol-3-phosphate acyltransferase GSK3β glycogen synthase kinase 3β HE hematoxylin-eosin HFD high-fat diet Insig2 insulin-induced gene 2 mTOR mechanistic target of rapamycin NAFLD non-alcoholic fatty liver disease OA oleic acid PPARγ peroxisome proliferator-activated receptor γ RYGB Roux-en-Y Gastric Bypass S6 ribosomal protein S6 S6K1 p70 ribosomal protein subunit 6 kinase 1 SREBP1c sterol response element-binding protein 1c mTOR AKT2 Insig2 RYGB Hepatic lipogenesis
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