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Up-regulation of NDRG2 through nuclear factor-kappa B is required for Leydig cell apoptosis in both human and murine infertile testes
Authors:Teng Li  Jing Hu  Gong-Hao He  Yun LiChu-Chao Zhu  Wu-Gang HouShun Zhang  Wei LiJin-Shan Zhang  Zhe WangXin-Ping Liu  Li-Bo Yao  Yuan-Qiang Zhang
Institution:
  • a Department of Human Anatomy, Histology and Embryology, The Fourth Military Medical University, Xi'an 710032, China
  • b Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China
  • c Department of Pathology, The Fourth Military Medical University, Xi'an 710032, China
  • d Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an 710032, China
  • Abstract:
    Keywords:B2M  beta-2-microglobulin  ChIP  chromatin immunoprecipitation  DAB  diaminobenzidine  EDS  ethane-dimethanesulfonate  EdU  5-ethynyl-2&prime  -deoxyuridine  FBS  fetal bovine serum  gapdh  glyceraldehyde-3-phosphate dehydrogenase  hprt1  hypoxanthine phosphoribosyl-transferase 1  3β-HSD  3β-hydroxysteroid dehydrogenase  17β-HSD  17β-hydroxysteroid dehydrogenase  MA  maturation arrest  MAA  methoxyacetic acid  ndrg2  N-myc downstream-regulated gene 2  NF-κB  nuclear factor-kappa B  PDTC  pyrrolidine dithiocarbamate  RIP-1  regulated intramembrane proteolysis-1  TNF-α  tumor necrosis factor-alpha  PI  propidium iodide  TUNEL  terminal deoxynucleotidyl transferase dUTP nick end labeling  SCO  Sertoli cell only syndrome
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