Potentiation of dietary restriction-induced lifespan extension by polyphenols |
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Authors: | Daniel J Aires Graham RockwellTing Wang Jennifer FronteraJo Wick WenFang Wang Marija Tonkovic-CapinJianghua Lu Lezi EHao Zhu Russell H Swerdlow |
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Institution: | a Division of Dermatology, University of Kansas, KS 66160, USAb Department of Bioinformatics, Boston University, MA 02215, USAc Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USAd Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS 66160, USAe Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS 66160, USAf Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USAg Department of Clinical Laboratory Sciences, University of Kansas Medical Center, Kansas City, KS 66160, USAh Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USAi Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA |
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Abstract: | Dietary restriction (DR) extends lifespan across multiple species including mouse. Antioxidant plant extracts rich in polyphenols have also been shown to increase lifespan. We hypothesized that polyphenols might potentiate DR-induced lifespan extension. Twenty week old C57BL/6 mice were placed on one of three diets: continuous feeding (control), alternate day chow (Intermittent fed, IF), or IF supplemented with polyphenol antioxidants (PAO) from blueberry, pomegranate, and green tea extracts (IF + PAO). Both IF and IF + PAO groups outlived the control group and the IF + PAO group outlived the IF group (all p < 0.001). In the brain, IF induced the expression of inflammatory genes and p38 MAPK phosphorylation, while the addition of PAO reduced brain inflammatory gene expression and p38 MAPK phosphorylation. Our data indicate that while IF overall promotes longevity, some aspects of IF-induced stress may paradoxically lessen this effect. Polyphenol compounds, in turn, may potentiate IF-induced longevity by minimizing specific components of IF-induced cell stress. |
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Keywords: | Longevity Dietary restriction Polyphenol Tea Blueberry Pomegranate |
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