PET1402, a nuclear gene required for proteolytic processing of cytochrome oxidase subunit 2 in yeast |
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Authors: | Mathias Bauer Meinhardt Behrens Karlheinz Esser Georg Michaelis and Elke Pratje |
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Institution: | (1) Institut für Allgemeine Botanik, Universität Hamburg, Ohnhorststr. 18, 22609 Hamburg, Germany;(2) Botanisches Institut, Universität Diisseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany |
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Abstract: | The nuclear mutation pet ts1402 prevents proteolytic processing of the precursor of cytochrome oxidase subunit 2 (cox2) in Saccharomyces cerevisiae. The structural gene PET1402 was isolated by genetic complementation of the temperature-sensitive mutation. DNA sequence analysis identified a 1206-bp open reading frame, which is located 215 by upstream of the PET122 gene. The DNA sequence of PET1402 predicts a hydrophobic, integral membrane protein with four transmembrane segments and a typical mitochondrial targeting sequence. Weak sequence similarity was found to two bacterial proteins of unknown function. Haploid cells containing a null allelle of PET1402 are respiratory deficient. |
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Keywords: | Mitochondria Protein sorting Cytochrome oxidase Post-translational proteolysis Chromosome V |
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