The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus |
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| Authors: | William P Hanratty and Charles R Dearolf |
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| Institution: | (1) Department of Biological Sciences, University of Southern Mississippi, 39406 Hattiesburg, MS, USA;(2) Department of Radiation Oncology, Harvard Medical School, Dana Farber Cancer Institute, 02115 Boston, MA, USA;(3) Present address: Dana Farber Cancer Institute, Room JF 209, 44 Binney Street, 02115 Boston, MA, USA |
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| Abstract: | The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development. |
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| Keywords: | Drosophila melanogaster Tumorous-lethal gene hopscotch gene Hematopoiesis |
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