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Photobiocatalyzed asymmetric reduction of ketones using Chlorella sp. MK201 |
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| Authors: | Ken-ichi Itoh Kaoru Nakamura Tadashi Aoyama Ryusuke Matsuba Tsuyoshi Kakimoto Masahiko Murakami Rio Yamanaka Toshiya Muranaka Hiroshi Sakamaki Toshio Takido |
| Institution: | 1. Department of Liberal Arts and Science, College of Science and Technology, Nihon University, 7-24-1 Narashinodai, Funabashi-shi, Chiba, 274-8501, Japan 2. Graduate School of Human Development and Environment ‘Science Shop’, Kobe University, 3-11 Tsurukabuto, Nada-ku, Kobe-shi, Hyogo, 657-8501, Japan 3. Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan 4. Faculty of Pharmaceutical Science, Himeji Dokkyo University, 7-2-1 Kamioono, Himeji-shi, Hyogo, 670-5824, Japan 5. Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita-shi, Osaka, 565-0871, Japan |
| Abstract: | Aromatic ketones were reduced using suspension culture of Chlorella sp. MK201 under fluorescent light illumination producing the corresponding chiral alcohols in high yields with excellent enantiomeric excess (ee). For example, 2′,3′,4′,5′,6′-pentafluoroacetophenone at 0.25?mg/ml was converted to the corresponding (S)-alcohol in 80?% yield with?>99?% ee by 1?mg dry wt of Chlorella/ml in 12?h illumination (2,000 lux). |
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